TAHAR Smaili

BEN MATOUG Baderezzaman , LAIB Abir

Etude biologique et phytochimique du genre Eryngium

Abstract :Weight reduction is basic therapy for obese and or diabetic persons. Since it is difficult to achieve through conventional therapy, medicinal plants have developed alternative therapy for these patients in current time due to its significant effectiveness in terms of glucose-weight reduction and stability. Obesity is a major risk for the diabetes development and predisposes individuals to hypertension and dyslipidaemia. It raises a serious challenge, explicitly, how to control blood glucose, blood pressure, and lipids when many antidiabetic agents cause weight gain and thereby exacerbate other cardiovascular risks associated with Diabetes. Many obese diabetic patients who are, hypertensive, and/or hyperlipidaemic fail to achieve blood pressure, lipid and glycaemic goals, and this failure may in part be explained by physician reluctance to utilize complex combination regimens for fear of off target effects. While conventional drug therapy remains an subtle average, newer medicinal plants, including Centaurea species, may offer greater diabetes therapy and obesity reduction and cardiovascular risk reduction and reduce weight and blood pressure and improve lipid profiles than other antidiabetes therapies, Integration of Centaurea species therapies into the therapeutic trials is a promising approach to improving outcomes in obese health, and perhaps even in reducing complications of diabetes, such as hypertension and dyslipidaemia. Additional long-term studies will be necessary to determine the appropriate places for therapies. Some Centaurea species had long been used in folk medicine for treating various diseases such as gynecological problems, digestive and dermatological complaints; in addition they are said to be weight neutral but also appear to improve lipid profiles. Chemical studies showed the presence of many compounds belonging mainly to the groups of sesquiterpene lactones, flavonoids and lignans.The present paper is devoted to assess the traditional uses, the current phytochemical and biological investigations of extracts and non volatile compounds of Centaurea sp., in order to highlight their potential as candidates for new drugs discovery, and natural diabetes therapeutic targeting and obesity reduction management. The general effects of Centaurea species possibly strongly relate to structure-activity relationships; although definitive clinical trial data are needed.

Citation

Tahar SMAILI , ,(2025-07-16), Centaurea specie effect on diabetes therapy and obesity reduction,International Conference on Obesity Therapies and Diabetes Research (ICOTDR-25),University of Istanbul, Turkey

Abstract Driven by the increasing interest in the incorporation of naturally derived ingredients in functional foods, researchers have placed greater emphasis on the process of identifying bioactive constituents from medicinal plants, as they can provide health benefits and nutritional potential. This study offers a phytochemical profiling and bioactivities investigation conducted for the first time for an Algerian wild Foeniculum vulgare subsp. capillaceum, focusing on its potential for functional food applications. Extracts from the aerial portions of the plant were prepared using a sequence of solvents, starting from n-hexane, followed by acetone, methanol, and finally deionized water to efficiently separate compounds based on their solubility characteristics. Subsequently, these extracts were subjected to a detection, characterization, and precise quantification of the diverse phenolic constituents present in the samples with LC-MS/MS. A total of 17 phenolic metabolites were characterized, with rutin and chlorogenic acid emerging as the major constituents. Among the extracts, the methanolic fraction demonstrated the greatest concentration of overall identified phenolic compounds (11.874 mg/g), accompanied by notable antioxidant capacity reflected in its effective neutralization of free radicals, recording IC₅₀ measurements of 28.69 µg/mL for DPPH radical and 24.72 µg/mL for ABTS cations. Interestingly, the hexanic extract demonstrated the strongest α-amylase inhibition (50.06% at 400 µg/mL), suggesting antidiabetic potential, while the acetonic extract displayed notable antibacterial activity, particularly against Micrococcus luteus (MIC = 1.56 mg/mL). These findings highlight F. vulgare subsp. capillaceum as a rich reservoir of compounds with biological activities positions it as a promising addition to functional foods designed to improve nutritional value and safety. Keywords: Foeniculum vulgare subsp. capillaceum; LC‐ESI‐MS/MS; antibacterial activity; antioxidant activity; phenolic compounds; α‐amylase inhibition.

Citation

Tahar SMAILI , , (2025-07-02), Chemical Profiling via LC-ESI-MS/MS and Functional Bioactivities of Foeniculum vulgare subsp. Capillaceum: Insights Into Antioxidant, Antidiabetic, and Antibacterial Potentials for Food Applications, Journal of Food Science, Vol:90, Issue:7, pages:1750-3841, Pub Med Central (PMC)