MALIKA Merzougui
مليكة مرزوقي
malika.merzougui@univ-msila.dz
0672413536
- Departement of Physics
- Faculty of Sciences
- Grade PHd
About Me
Location
sidi ameur, sidi ameur
Msila, ALGERIA
Code RFIDE- 1992-11-14 00:00:00
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MALIKA Merzougui birthday
- 2025-11-09
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2025-11-09
Si effect on the thermal stability and parameters lattice of hydroxyapatite synthesized by the sol-gel route
Hydroxyapatite (HA) is a biocompatible and bioactive material used as a bone substitute material in orthopedics and dentistry. The aim of this work is the study of the effect of the silicium addition (Si) with different molar ratio (0, 1, 5 and 10 %) on the thermal stability and lattice parameters of the hydroxyapatite synthesized by the sol-gel route. Triethyl phosphate (TEP), calcium nitrate tetrahydrate and Tetraethyl Orthosilicate (TEOS) were used as sources of phosphorus, calcium and silicon, respectively. All dried gels were heat treated at 700 ℃ for 1 h in order to decompose all organic matters formed during the synthesis. After that, the calcined powders were heat treated at 1100, 1200 and 1300 ℃ for 2 hours. XRD and FTIR results of powders calcined at 700 ℃ showed the formation of hydroxyapatite as a major phase and CaO as a secondary phase. -tricalcium phosphate (-TCP) didn’t formed. In addition, the intensity of characteristic peaks of HA increased, while the intensity of the peak characteristic of CaO decreased with Si ratio. According to the calculus of the lattice parameters, it was observed a decrease in the a-axis and an increase in the c-axis of the unit cell of Si- doped hydroxyapatite. This is due to the replacement of phosphate ions with silicate ions and the loss of the OH group. The ratio of OH group decreases in order to balance the charge because the phosphate ions are trivalent and silicate ions are tetravalent. Also, a decrease in the grain size of the Si-doped samples and a slight increase in the degree of crystallinity were observed. Furthermore, it was observed that the molar ratio (Ca/P+Si) decreased from 1.97 to 1.80 with increasing Si concentration. Also, XRD of pure HA and Si-doped HA powders, heat treated at 1100, 1200 and 1300 ℃ showed that HA phase remains with no secondary phases (-TCP) formation. So, HA phase is stable in all powders at all temperatures, the decomposition of HA was not occurred. According to the obtained results, it can be conclude that the substitution of Si atoms in the sites of phosphorus did not affect the stability of HA and it leads to the improvement of the HA crystallization. For the antibacterial test realized with the bacteria E.coli showed that the inhibition zone increased with Si concentration. So, Si-doped hydroxyapatite can be use inside the human body without negative effects.
Citation
Fatima Zohra MEZAHI , malika MERZOUGUI , ACHOUR Dakhouche , ,(2025-11-09), Si effect on the thermal stability and parameters lattice of hydroxyapatite synthesized by the sol-gel route,International Conference on Nano science and Nanotechnology (IC2N),Doha, Qatar
- 2022
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2022
Caracterisation of doped hydroxyapatite by magnesium versus the heat treatment temperature
The aim of this work is to study the effect of magnesium on the physic-chemical properties of hydroxyapatite prepared by sol-gel route. Magnesium Nitrate Hexahydrate, Calcium Nitrate tetrahydrate, and triethyl phosphate (TEP) were used as precursors for Mg, Ca, and P, respectively. Noted that the molar ratio (Ca +Mg)/P was kept constant at 1.67 when the magnesium was added (0 to 10 % (mol)) to the prepared solutions. Based on the our previous results, all solutions were aged at 70°C for 24 h, the distilled water was used as medium solvent. The same conditions were used for gelling and drying of the aged solutions. All dried gels were calcined at 700°C for 1 h and heat treated at 1100, 1200 and 1300°C for 4 h in order to study the effect of magnesium on the crystallization of doped hydroxyapatite (Ca10-xMgx (PO4)6(OH)2, crystal lattice parameters, thermal stability and morphological of hydroxyapatite. The XRD and FTIR results showed that the hydroxyapatite is the major formed phase at all temperatures without any decomposition to the tricalcium phosphate. The CaO was present as secondary phase at 700°C. But the intensity of this phase decreased with temperature. Also, a minor ratio of MgO was present in samples doped by 5% and 10% MgO. The lattice parameters of doped hydroxyapatite decreased in comparison to pure hydroxyapatite because the ion radius of magnesium is lower than that of calcium. The results of analysis of distribution size confirmed the formation of agglomerates as results of the assemblage of small grains as confirmed by SEM images. The obtained results confirmed the incorporation of the magnesium in the lattice structure of HA.
Citation
Fatima Zohra MEZAHI , malika MERZOUGUI , ,(2022), Caracterisation of doped hydroxyapatite by magnesium versus the heat treatment temperature,2nd International Seminar on Industrial Engineering and Applied Mathematics (ISIEAM’22),Skikda , Algérie
- 2018
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2018
Sodium effect on the hydroxyapatite synthesis by the sol-gel route
Hydroxyapatite (HA) Ca10 (PO4)6 (OH)2 is a very important inorganic material; first mineral constituent of bones, tooth enamel and dentin. It is very flexible in terms of composition and morphology. HA is known as a non-resorbable and surface-active bioceramic and is mainly used for many medical applications thanks to its biocompatibility and bioactivity. The aim of this work is devoted to study of the effect of the sodium addition (Na) with different molar ratio (0, 1, 5, 10, 15 and 20%) on the synthesis of hydroxyapatite by the sol-gel route. From the obtained results, it was possible to obtain well crystallized hydroxyapatite at 700 ° C; synthesized from the precursors: the calcium nitrate and tri-ethyl phosphate. Sodium nitrates were used as a source of Na. The synthesis was carried out for 3 days; one day for aging the prepared solutions; one day to obtain a gel, one day to dry the gel. The obtained results showed that the addition of sodium stabilize the hydroxyapatite synthesized by the sol-gel route. As ratio of Na increases, the intensity of the XR peaks of HA increases and that of CaO decreases. Thus, DRX has shown the apparition of a new phase (-CaNaPO4) at 1000 ° C and 1300 ° C for the large concentrations of Na (15 % and 20 %).
Citation
Fatima Zohra MEZAHI , malika MERZOUGUI , ,(2018), Sodium effect on the hydroxyapatite synthesis by the sol-gel route,International conference on Materials Science ICMS2018,Setif